Complex chemistry with complex compounds

Predicting complex biology with simple chemistry.

O ne of the most important activities in science is the development of models, i.e., simpler representations, often by mathematical equations, of more complex systems, which capture key aspects of those systems. A model, of course, cannot be identical to its target system and must discard at least some of the features of the full system while focusing on those characteristics that the modeler c...

Probing complex biological systems with simple chemistry.

A simplified chemical model helps elucidate the spatiotemporal dynamics of blood clotting.

INTERACTION OF DOXORUBICIN WITH DNA-HMG1 COMPLEX

In this study, the interaction of the anthracycline antibiotic doxorubicin with DNA-HMG 1 complex was investigated employing UV/VIS spectroscopy, thermal denaturation and DNA cellulose chromatography techniques. The results indicated that the binding of doxorubicin to the protein reduces its Tm in a dose dependent manner. Although doxorubicin protects free DNA against thermal denaturation ...

From Simple to Complex Compounds

Mineral chemistry and thermobarometry of amphibolites from the Qotur metamorphic complex (West Azerbaijan Providence, NW Iran)

The Qotur metamorphic complex consists of metabasites, gneisses, marbles and calc-silicates as well as serpentinites which is cropped out at the west border of West Azerbaijan and Turkey. The amphibolites from the Qotur metamorphic complex can be classified as two types of ortho- and para-amphibolites. Minerals in this ortho-amphibolite are hornblende, plagioclase, zircon, titanite, and opaque ...